Formulation and in vitro evaluation of fast dissolving tablets of metoprolol tartrate
نویسندگان
چکیده
منابع مشابه
Formulation development and comparative in vitro study of metoprolol tartrate (IR) tablets.
The objective of the present work was to develop Immediate Release (IR) tablets of Metoprolol Tartrate (MT) and to compare trial formulations to a reference product. Six formulations (F1-F6) were designed using central composite method and compared to a reference brand (A). Two marketed products (brands B and C) were also evaluated. F1-F6 were prepared with Avicel PH101 (filler), Crospovidone (...
متن کاملLopressor® metoprolol tartrate tablets, USP, metoprolol tartrate injection, USP
Lopressor, metoprolol tartrate USP, is a selective beta1-adrenoreceptor blocking agent, available as 50and 100-mg tablets for oral administration and in 5-mL ampuls for intravenous administration. Each ampul contains a sterile solution of metoprolol tartrate USP, 5 mg, and sodium chloride USP, 45 mg, and water for injection USP. Metoprolol tartrate USP is (±)-1 (Isopropylamino)-3-[p-(2-methoxy...
متن کاملFormulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers.
In view of the circadian rhythm of cardiovascular diseases, a delayed-onset extended-release (DOER) formulation of metoprolol tartrate (MT) was prepared. This was achieved through dissolution-guided optimization of the proportion of Methocel K4M and Methocel K15M. Core erosion ratio was greater than 50 %, thereby showing steady release of the drug after the lag time until complete dissolution. ...
متن کاملFormulation and Evaluation of Chrono Modulated Time Release Tablets of Metoprolol Tartrate
The aim of the present work is to design an oral time release tablet by press coating method to achieve a distinct predetermined lag time. In this study Metoprolol tartrate was selected as the model drug. The outer shell was formulated with different weight ratios of Hydroxy propyl methyl cellulose K100M and Ethyl cellulose to achieve a release profile with pre determined lag time. The lag time...
متن کاملFormulation and Evaluation of Mouth Dissolving Tablet of Zolpidem Tartrate
Conventional solid dosage form suffers from problem like difficulty in swallowing with age, onset of action and physiological factor of patient like gastric emptying time. To overcome this mouth dissolving tablet is a newer approach to drug delivery. Zolpidem is preferentially used for the short term treatment of insomnia. The aim of present study is to formulate and evaluate mouth dissolving t...
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ژورنال
عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences
سال: 2013
ISSN: 1984-8250
DOI: 10.1590/s1984-82502013000400018